Adolescence follows the case of Jamie Miller, a 13-year-old boy accused of murdering his classmate, Katie Leonard. Each episode follows events in real-time, starting with Jamie's arrest in episode 1, followed by the police investigation and the impact on Jamie's friends and classmates 72 hours later in episode 2.

The moving but agonizing tale about a young boy named Jamie (Owen Cooper) who is accused of murdering his female classmate is a harrowing watch, as the four episodes chronicle his arrest, a psych evaluation,

It begins with one of the most devastating scenes as 13-year-old Jamie Miller, played by newcomer Owen Miller, is accused of murdering his schoolmate, Katie. Throughout the ordeal, Jamie maintains his innocence and insists that he didn't do it.