Innate immunity, orchestrated by pattern recognition receptors (PRRs) including TLRs, NLRs, and the cGAS–STING pathway, forms the foundation of host ...

Cardiovascular diseases (CVDs) remain the leading cause of death worldwide and are now increasingly recognized as conditions with a strong ...

The innate immune response constitutes the body’s first line of defence against pathogens, utilising a network of pattern recognition receptors (PRRs) and signalling molecules to detect and neutralise ...

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterised by the production of autoantibodies and the formation of immune complexes, leading to inflammation and multi-organ ...

When a transplanted organ arrives, it’s like a controlled burn that risks becoming a wildfire. The body’s innate immune system senses damage signals, like heat shock proteins (HSP70), and sounds the ...

The immune system can work in two ways: the innate immune system reacts to any foreign invaders that are identified by immune cells that look for such pathogens; but the acquired or adaptive immune ...

Once the adaptive response takes care of the threat, the innate response is called back in to clean up the mess, disposing of dead cells in damaged tissues, and ultimately signaling an end to the ...

Fred Hutch Cancer Center molecular biologist Dr. Kevin Barry just received a $270,000, two-year grant from the American ...

A macrophage that has already fought off one infection does not return to a blank slate. It carries chemical scars, etched ...

Immune checkpoint inhibitors (ICIs) have revolutionized the landscape of cancer management. However, acquired resistance and response variability point to rational combination strategies as the goal ...

Unlike transient innate immune activation, trained immunity is characterized by long-lasting but reversible functional reprogramming of monocytes, macrophages, natural killer (NK) cells, and ...

Lacutamab is a first-in-class anti-KIR3DL2 humanized cytotoxicity-inducing antibody that is currently in clinical trials for treatment of cutaneous T-cell lymphoma (CTCL), an orphan disease, and ...