Insulin resistance is an integral pathophysiological feature of type 2 diabetes mellitus. Here, we review established and emerging cellular mechanisms of insulin resistance, their complex integrative ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study by a team at the Max Planck Institute ...

Insulin resistance plays a role in many diseases. The new research provides insights into why insulin resistance appears to be associated with neurodegenerative disorders. Corresponding author Kai ...

Developing resistance to insulin is a key step on the road to diabetes, making insulin resistance a target for treating metabolic dysfunction. Insulin orchestrates blood glucose levels by signaling ...

Energy balance and body weight are regulated by hypothalamic nuclei such as the arcuate nucleus (ARC) and influenced by signals from the periphery, such as insulin. How energy balance becomes ...

A new study focuses on the insulin receptor to understand its role in the development of type 2 diabetes mellitus, a metabolic disease with a major impact on global health. Insulin resistance precedes ...

In 2021, a research team discovered the insulin-inhibitory receptor 'Inceptor' and its role as a suppressor of the insulin signaling pathway. Now, the researchers have unlocked another, even more ...

It’s easy to blame sugar, but experts say the true cause of insulin resistance may start elsewhere.

Three years ago, the inceptor protein was discovered and its role as an inhibitor of the insulin signaling pathway was described. Inceptor and the insulin receptor are located on the surface of beta ...

The improvements extended well beyond weight loss. Average HbA1c levels declined from 6.45 to 5.78, moving below the ...

Dr J.C. Suri explains how bad sleep can drive insulin resistance. Here is why this happens and the early signs that may ...

How does insulin resistance affect your liver and overall health? HelloNation has published the piece and provides the answer ...