Week 12 of the 2025 NFL season kicks off on Thursday night when the Buffalo Bills visit the Houston Texans and wraps up Monday night with Christian McCaffrey's San Francisco 49ers facing off against the tailback's former franchise, the Carolina Panthers.

The Buffalo Bills (7-3) visit the Houston Texans (5-5) at NRG Stadium in Houston for a Week 12 showdown, and USA TODAY's panel of NFL experts have locked in their picks and predictions for the action.