Accurate RNA splicing is essential for gene expression and human health, yet predicting how DNA sequence variations affect ...

Although heart cells and skin cells contain identical instructions for creating proteins encoded in their DNA, they're able to fill such disparate niches because molecular machinery can cut out and ...

Johns Hopkins researchers have developed a powerful new AI tool called "Splam" that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with greater ...

Measuring splicing and chromatin accessibility simultaneously in frozen tissues remains challenging. Here we combined single-cell isoform RNA sequencing and assay for transposase accessible chromatin ...

The Nature Index 2026 Research Leaders reveal the leading institutions and countries/territories in the natural sciences, health sciences, applied sciences and social sciences, according to their ...

Researchers at City of Hope and TGen (part of City of Hope) have identified a significant correlation between a tumor's "splicing burden" and its clinical response to treatment for metastatic renal ...