Nature

Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren’s disease

Sjögren’s disease in adults (aSjD) occurs mainly in peri-menopausal female patients with clinical hallmarks of dry mouth and dry eyes (sicca symptoms) 1. Of those, 30–40% of patients present extra ...
Nature

Single-cell characterization of macrophages in uveal melanoma uncovers transcriptionally heterogeneous subsets conferring poor prognosis and aggressive behavior

Uveal melanoma (UM) is the most frequent primary intraocular malignancy with high metastatic potential and poor prognosis. Macrophages represent one of the most abundant infiltrating immune cells with ...