Astros center fielder Jake Meyers stood at home plate in disbelief, echoing the feeling of a sellout crowd that had just ridden a roller-coaster of emotions in the span of about 10 seconds. Nervousness turned to excitement before giving away to disappointment.

The Houston Astros have ripped out the hearts of the Seattle Mariners plenty of times in downtown Houston, so the Mariners couldn't hide their excitement after a huge sweep at Daikin Park.

Yordan Alvarez is eligible to return Friday in Anaheim, but has yet to resume baseball activities after suffering a sprained ankle.

For the second straight game, the Houston Astros fell to the Seattle Mariners, this time by a score of 6-4 on Saturday at Daikin Park.

The Seattle Mariners face the Houston Astros in a regular season MLB game on Sunday, Sept. 21, 2025 (9/21/25) at Daikin Park in Houston, Texas.

An injury-ravaged Astros season is down to its final stretch, with Houston having six games to try to extend its playoff streak to nine years.

Preview the Sept. 20 matchup between the Houston Astros and Seattle Mariners with recent trends, how to watch, livestream info, and more.

Astros shortstop Jeremy Pena, who has 17 home runs and 62 RBIs this season, was scratched from Sunday night's game vs. the Mariners with left oblique soreness.

In the 64-year history of the franchise, the Houston Astros have hit 2.7 million fans in attendance 13 times, including in 2025.

Preview the Sept. 21 matchup between the Seattle Mariners and Houston Astros with recent trends, how to watch, livestream info, and more.