Christian McCaffrey, Kyren Williams, & Najee Harris have carried heavy workloads in their NFL careers. Injury concerns will raise caution in fantasy football.

The 49ers likely have no intention of playing starter Christian McCaffrey in the preseason, backup Isaac Guerendo is out for ...

When the 49ers offense is healthy, it's one of the best in the NFL. Unfortunately, their offense wasn't healthy last year, and it isn't healthy now.

The 49ers are hoping to rebound from a lost season in 2024 and Christian McCaffrey's return from injury will be a major boost ...

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

Mackenzie Brooks and the Inside the Lines Team break down where every NFC West team's season is most likely to end and how to ...

San Francisco 49ers running back Christian McCaffrey explained why he sometimes feels uneasy sleeping in a hotel room amid ...

Evaluating the risk-factors of Christian McCaffrey and his ability to be drafted in the first round of your fantasy football ...

Christian McCaffrey has some dad guilt as football preseason heats up. The San Francisco 49ers running back has been busy in ...

All signs point to Aiyuk starting the season on the reserve/PUP list, which would sideline him for the first four weeks of ...

Two top contenders this year face off in the preseason opener, with the San Francisco 49ers hosting the Denver Broncos. However, many fans are wondering whether stars Christian McCaffrey and Bo Nix ...

A high ankle sprain could keep Jordan Watkins from covering for Brandon Aiyuk, Demarcus Robinson when season starts.