Get Milwaukee vs Pittsburgh baseball betting preview, spread and over/under insights for their matchup on May 22.

Welcome to PNC Park, the home of the Pittsburgh Pirates. Tucked into the banks of the Allegheny River, the beauty of the ‘Burgh was named the top stadium in baseball, according to a 2025 USA Today ranking. One day at the ballpark is all you need to figure out why.

The Milwaukee Brewers sit at 24-26 on the season as they’ll head east to take on the Pittsburgh Pirates for a four-game series at PNC Park. This series marks their first National League opponent since the first weekend of May,

Pittsburgh Pirates fans haven't had much to cheer about this season, which probably explains why many of them have stopped going to games altogether. This fact

It was more of the same for the Pittsburgh Pirates in a 7-1 loss to the Cincinnati Reds at PNC Park on Monday night. Mitch Keller provided a strong start, but the offense was all but silenced against Reds starter Nick Lodolo and three relievers.

That thinking drove ESPN baseball insider Jeff Passan to explain a similar line of thinking, as he pointed out that Skenes is virtually guaranteed to leave the Pirates when he becomes eligible for free agency, given the state of the franchise. By trading him now, Passan argued, the team could recoup a lot of his future value before that happens.

It's Thursday, May 22 and the Brewers (24-26) are in Pittsburgh to take on the Pirates (17-33). Milwaukee has not announced its starter yet, while Mike Burrows makes his 2025 debut for Pittsburgh. The Pirates snapped a four-game losing streak with back-to-back wins over the Reds in the last two days.

Pregame analysis and predictions of the Milwaukee Brewers vs. Pittsburgh Pirates MLB game to be played on May 22, 2025 on ESPN.